Publication

2020

Cas­tro-Gon­za­lez, S., Shi, Y., Colom­er-Lluch, M., Song, Y., Mow­ery, K., Almod­ovar, S., Bansal, A., Kirch­hoff, F., Spar­rer, K., Liang, C., et al. (2020). HIV‑1 Nef coun­ter­acts autophagy restric­tion by enhanc­ing the asso­ci­a­tion between BECN1 and its inhibitor BCL2 in a PRKN-depen­dent man­ner. Autophagy, 1 – 25.

Fuchs, N.V., Schieck, M., Neuenkirch, M., Ton­dera, C., Schmitz, H., Steine­mann, D., Gohring, G., and König, R. (2020). Induced pluripo­tent stem cell line (PEIi003‑A) derived from an appar­ent­ly healthy male indi­vid­ual. Stem cell research 42, 101679.

Ick­ler, J., Fran­cois, S., Widera, M., San­ti­a­go, M.L., Dittmer, U., Sut­ter, K. (2020). HIV infec­tion does not alter inter­fer­on alpha/​beta recep­tor 2 expres­sion on mucos­al immune cells. PLoS One 15, e0218905.

Joas, S., Sauer­mann, U., Roshani, B., Klip­pert, A., Daskala­ki, M., Matz-Rens­ing, K., Stolte-Leeb, N., Heigele, A., Tharp, G.K., Gup­ta, P.M., Nel­son, S., Bosinger, S., Par­o­di, L., Giave­doni, L., Sil­vestri, G., Sauter, D., Stahl-Hen­nig, C., Kirch­hoff, F. (2020). Nef-Medi­at­ed CD3-TCR Down­mod­u­la­tion Damp­ens Acute Inflam­ma­tion and Pro­motes SIV Immune Eva­sion. Cell reports 30, 2261 – 2274.e2267.

Kmiec, D., Nchioua, R., Sher­rill-Mix, S., Sturzel, C.M., Heusinger, E., Braun, E., Gondim, M.V.P., Hot­ter, D., Spar­rer, K.M.J., Hahn, B.H., Sauter, D., Kirch­hoff, F. (2020). CpG Fre­quen­cy in the 5′ Third of the env Gene Deter­mines Sen­si­tiv­i­ty of Pri­ma­ry HIV‑1 Strains to the Zinc-Fin­ger Antivi­ral Pro­tein. mBio 11.

Pre­vost, J., Edgar, C.R., Richard, J., Trothen, S.M., Jacob, R.A., Mum­by, M.J., Pick­er­ing, S., Dube, M., Kauf­mann, D.E., Kirch­hoff, F., Neil, S.J.D., Finzi, A., Dikeakos, J. D. (2020). HIV‑1 Vpu down­reg­u­lates Tim‑3 from the sur­face of infect­ed CD4(+) T cells. Jour­nal of virol­o­gy.

Yin, X., Langer, S., Zhang, Z., Her­bert, K.M., Yoh, S., König, R., and Chan­da, S.K. (2020). Sen­sor Sen­si­bil­i­ty-HIV‑1 and the Innate Immune Response. Cells 9.

Zutz, A., Scholz, C., Schnei­der, S., Pieri­ni, V., Munch­hoff, M., Sut­ter, K., Wittmann, G., Dittmer, U., Draen­ert, R., Bogn­er, J.R., Fack­ler, O.T., Kep­pler, O.T. (2020). SERINC5 Is an Uncon­ven­tion­al HIV Restric­tion Fac­tor That Is Upreg­u­lat­ed dur­ing Myeloid Cell Dif­fer­en­ti­a­tion. Jour­nal of innate immu­ni­ty, 1 – 11.

2019

Al-She­habi, H., Fiebig, U., Kutzn­er, J., Den­ner J., Schaller, T., Ban­nert, N., Hof­mann, H. (2019). Human SAMHD1 restricts the xeno­trans­plan­ta­tion rel­e­vant porcine endoge­nous retro­virus (PERV) in non-divid­ing cells. J Gen Virol. 100(4):656 – 661.

Ananth, S., Morath, K., Trautz, B., Tibroni, N.,  Shy­taj, I.A., Ober­maier, B., Stolp, B., Lusic, M. and Fack­ler, O.T. (2019). Mul­ti­func­tion­al Roles of the N‑Terminal Region of HIV‑1SF2Nef Are Medi­at­ed by Three Inde­pen­dent Pro­tein Inter­ac­tion Sites. J. Virol. Pub­lished online ahead of print Oct 9 2019. https://doi.org/10.1128/JVI.01398 – 19.

Baal, N., Cun­ning­ham, S., Ober­mann, H.L., Thomas, J., Lip­pitsch, A., Dietert, K., Gru­ber, A.D., Kauf­mann, A., Michel,G., Nist, A., Stiewe, T., Rupp, O., Goes­mann, A., Zukun­ft, S., Flem­ing, I., Bein, G., Lohmey­er, J., Bauer, S., Hack­stein, H. (2019) ADAR1 Is Required for Den­drit­ic Cell Sub­set Home­osta­sis and Alve­o­lar Macrophage Func­tion. (2019). J Immunol, 202:1099 – 1111.

Bejara­no, D.A., Peng, K., Lake­ta, V., Börn­er, K., Jost, K.L., Lucic, B., Glass, B., Lusic, M., Müller, B., Kräus­slich, H.G. (2019). HIV‑1 nuclear import in macrophages is reg­u­lat­ed by CPS­F6-cap­sid inter­ac­tions at the Nuclear Pore Com­plex. eLife, 8:e41800

Braun, E., Hot­ter, D., Koep­ke, L., Zech, F., Groß, R., Müller, J., Wom­bach­er, R., Sut­ter, K., Dittmer, U., Win­kler, M., Sim­mons, G., Pöhlmann, S., Münch, J., Fack­ler, O.T., Kirch­hoff, F. and Sauter D. Guany­late-bind­ing pro­teins 2 and 5 exert broad antivi­ral activ­i­ty by inhibit­ing furin-medi­at­ed pro­cess­ing of viral enve­lope pro­teins. Cell Reports (in press).

de Sousa-Pereira, P., Abrantes, J., Bauern­fried, S., Pieri­ni, V., Esteves, P.J., Kep­pler, O.T., Piz­za­to, M., Hor­nung, V., Fack­ler, O.T., Bal­dauf, H.M. (2019) The antivi­ral activ­i­ty of rodent and lago­morph SERINC3 and SERINC5 is coun­ter­act­ed by known viral antag­o­nists. J Gen Virol, 100:278 – 288.

Hot­ter, D., Bosso, M., Jøns­son, K.L., Krapp, C., Stürzel, C.M., Das, A., Lit­twitz-Salomon, E., Berk­hout, B., Russ, A., Wittmann, S., Gram­berg, T., Zheng, Y., Mar­tins, L.J., Planelles, V., Jakob­sen, M.R., Hahn, B.H., Dittmer, U., Sauter, D., Kirch­hoff, F. (2019) IFI16 tar­gets the tran­scrip­tion fac­tor Sp1 to sup­press HIV‑1 tran­scrip­tion and laten­cy reac­ti­va­tion. Cell Host & Microbe (in press).

Langer, S., Ham­mer, C., Hopfensperg­er, K., Klein, L., Hot­ter, D., De Jesus, P.D., Her­bert, K.M., Pache, L., Smith, N., van der Mer­we, J.A., Chan­da, S.K., Fel­lay, J., Kirch­hoff, F., Sauter, D. (2019). HIV‑1 Vpu is a potent tran­scrip­tion­al sup­pres­sor of NF-κB-elicit­ed antivi­ral immune respons­es. eLife, 8:e41930.

Osei Kuf­four, E., König, R., Häussinger, D., Schulz, W.A., Münk, C. (2019). ISG15 Defi­cien­cy Enhances HIV‑1 Infec­tion by Accu­mu­lat­ing Mis­fold­ed p53. MBio, 27;10. pii: e01342-19.

Yama­so­ba, D., Sato, K., Ima­mu­ra, T., Koep­ke, L., Joas, S., Rei­th, E., Hot­ter, D., Mis­awa, N., Aka­ki, K., Ueha­ta, T., Mino, T., Yamashita, A., Stan­d­ley, D.M., Kirch­hoff, F., Sauter, D., Koy­ana­gi Y., and Takeuchi, O. (2019) N4BP1 restricts HIV‑1 and its inac­ti­va­tion by MALT1 pro­motes viral reac­ti­va­tion. Nat. Microb.  Nature Micro­bi­ol­o­gy, 1.

2018

Ban­nert, N., Hof­mann, H., Block, A., Hohn, O. (2018). HERVs New Role in Can­cer: From Accused Per­pe­tra­tors to Cheer­ful Pro­tec­tors. Front Micro­bi­ol, 9:178.

Heusinger, E., Deppe, K., Sette, P., Krapp, C., Kmiec, D., Kluge, S., Marx, P., Ape­trei, C., Kirch­hoff, F., Sauter, D. (2018). Preadap­ta­tion of SIVs­mm facil­i­tat­ed Env-medi­at­ed coun­ter­ac­tion of human teth­erin by HIV‑2. J Virol, 92: pii: e00276-18.

Hot­ter, D., Kirch­hoff, F. (2018). Inter­fer­ons and beyond: induc­tion of anti­retro­vi­ral restric­tion fac­tors. J Leukoc Biol, 103:465 – 477.

Joas, S., Par­rish, E.H., Gnanadu­rai, C.W., Lump, E., Stürzel, C.M., Par­rish, N.F., Learn G.H., Sauer­mann, U., Neu­mann, E.,Mätz Rens­ing, K., Fuchs, D., Billings­ley, J.M., Bosinger, S.E., Sil­vestri, G., Ape­trei, C., Huot, N., Gar­cia-Tellez, T., Müller-Trutwin, M., Hot­ter, D., Sauter, D., Stahl-Hen­nig, C., Hahn, B.H., Kirch­hoff, F. (2018). Species-spe­cif­ic host fac­tors rather than virus intrin­sic vir­u­lence deter­mine pri­mate lentivi­ral path­o­genic­i­ty. Nat Com­mun, 9:1371.

Kmiec, D., Akbil, B., Ananth, S., Hot­ter, D., Spar­rer, K.M.J., Stürzel, C.M., Trautz, B., Ayou­ba, A., Peeters, M., Yao, Z., Stagl­jar, I., Pas­sos, V., Zillinger, T., Goffinet, C., Sauter, D., Fack­ler, O.T., Kirch­hoff, F. (2018). SIV­col Nef coun­ter­acts SERINC5 by pro­mot­ing its pro­tea­so­mal degra­da­tion but does not effi­cient­ly enhance HIV‑1 repli­ca­tion in human CD4+ T cells and lym­phoid tis­sue. PLoS Pathog, 14: pii: e1007269.

Lam­bert, C., Couteaudi­er, M., Gouzil, J., Richard, L., Mon­tange, T., Bet­sem, E., Rua, R., Tobaly-Tapiero, J., Lin­de­mann, D., Njouom, R., Mouin­ga-Ondémé, A., Ges­sain, A., Buseyne, F. (2018). Potent neu­tral­iz­ing anti­bod­ies in humans infect­ed with zoonot­ic simi­an foamy virus­es tar­get con­served epi­topes locat­ed in the dimor­phic domain of the sur­face enve­lope pro­tein. PLoS Pathog, 14:e1007293.

Lands­berg, C.D., Meg­ger, D.A., Hot­ter, D., Rück­born, M.U., Eil­brecht, M., Rashi­di-Alay­i­jeh, J., Howe, S., Hein­richs, S., Sauter, D., Sitek, B., Le-Trilling, V.T.K., Trilling, M. (2018). A Mass Spec­trom­e­try-Based Pro­fil­ing of Inter­ac­tomes of Viral DDB1- and Cullin Ubiq­ui­tin Lig­ase-Bind­ing Pro­teins Reveals NF-κB Inhibito­ry Activ­i­ty of the HIV-2-Encod­ed Vpx. Front Immunol, 9:2978.

Mor­ris, K.L., Buf­fa­lo, C.Z., Ren, C., Stürzel, C.M., Heusinger, E., Kirch­hoff, F., Hur­ley, J.H. (2018). HIV‑1 Nef is a car­go-sen­si­tive AP‑1 trimer­iza­tion switch in MHC‑I and teth­erin down­reg­u­la­tion. Cell, 174:659 – 671.

Osei Kuf­four, E., Schott, K., Jagu­va Vasude­van, A.A., Holler, J., Schulz, W.A., Lang, P.A., Lang, K.S., Kim, B., Häussinger, D., König, R., Münk, C. (2018). USP18 (UBP43) Abro­gates p21-Medi­at­ed Inhi­bi­tion of HIV‑1. J Virol, 92: pii: e00592-18.

Palesch, D., Bosinger, S.E., Tharp, G.K., Van­der­ford, T.H., Paiar­di­ni, M., Chahrou­di, A., John­son, Z.P., Kirch­hoff, F., Hahn, B.H., Nor­gren, R.B., Patel, N.B., Sodo­ra, D.L., Dawoud, R.A., Stew­art, C.-B., Seepo, S.M., Har­ris, R.A., Liu, Y., Raveen­dran, M., Han, Y., Eng­lish, A., Thomas, G.W.C., Hahn, M.W., Pipes, L., Mason, C.E., Muzny, D.M., Gibbs, R.A., Sauter, D., Wor­ley, K., Rogers, J., Sil­vestri, G. (2018). Sooty mangabey genome sequence pro­vides insight into AIDS resis­tance in a nat­ur­al SIV host. Nature, 553:77 – 81.

Sauter, D., Kirch­hoff, F. (2018). Mul­ti­lay­ered and ver­sa­tile inhi­bi­tion of cel­lu­lar antivi­ral fac­tors by HIV and SIV acces­so­ry pro­teins. Cytokine Growth Fac­tor Rev, 40:3 – 12.

Schott, K., Fuchs, N.V., Derua, R., Mah­boubi, B., Schnell­bäch­er, E., Seifried, J., Ton­dera, C., Schmitz, H., Shep­ard, C., Bran­dariz-Nuñez, A., Diaz-Grif­fero, F., Reuter, A., Kim, B., Janssens, V., König, R. (2018). Dephos­pho­ry­la­tion of the HIV‑1 restric­tion fac­tor SAMHD1 is medi­at­ed by PP2A-B55α holoen­zymes dur­ing mitot­ic exit. Nat Com­mun, 9:2227.

Sut­ter, K., Dick­ow, J., Dittmer U. (2018). Inter­fer­on α sub­types in HIV infec­tion. Cytokine Growth Fac­tor Rev. 40:13 – 18.

Qu, K., Glass, B., Doležal, M., Schur, F.K.M., Mur­ciano, B., Rein, A., Rumlová, M., Ruml, T., Kräus­slich, H.G., Brig­gs, J.A.G. (2018). Struc­ture and archi­tec­ture of imma­ture and mature murine leukemia virus cap­sids. Proc Natl Acad Sci U S A, 115:11751 – 11760.

Yama­da, E., Nakao­ka, S., Klein, L., Rei­th, E., Langer, S., Hopfensperg­er, K., Iwa­mi, S., Schreiber, G., Kirch­hoff, F., Koy­ana­gi, Y., Sauter, D., Sato, K. (2018). Human-Spe­cif­ic Adap­ta­tions in Vpu Con­fer­ring Anti-teth­erin Activ­i­ty Are Crit­i­cal for Effi­cient Ear­ly HIV‑1 Repli­ca­tion In Vivo. Cell Host Microbe, 23:110 – 120.

2017

Bal­dauf, H. M., Stegmann, L., Schwarz, S. M., Ambiel, I., Tro­tard, M., Mar­tin, M., Burggraf, M., Lenzi, G.M., Lejk, H., Pan, X., Fregoso, O.I., Lim, E.S., Abra­ham, L., Nguyen, L.A., Rutsch, F., König, R., Kim, B., Emer­man, M., Fack­ler, O.T., Kep­pler, O. T. (2017). Vpx over­comes a SAMHD1-inde­pen­dent block to HIV reverse tran­scrip­tion that is spe­cif­ic to rest­ing CD4 T cells. Proc Natl Acad Sci U S A, 114: 2729 – 2734.

Groh, S., Schot­ta, G. (2017). Silenc­ing of endoge­nous retro­virus­es by het­e­rochro­matin. Cell Mol Life Sci, 74: 2055 – 2065.

Heusinger, E., Kirch­hoff, F. (2017). Pri­mate Lentivirus­es Mod­u­late NF-κB Activ­i­ty by Mul­ti­ple Mech­a­nisms to Fine-Tune Viral and Cel­lu­lar Gene Expres­sion. Front Micro­bi­ol, 8:198.

Hof­mann, S., Dehn, S., Businger, R., Bold­u­an, S., Schnei­der, M., Debyser, Z., Brack-Wern­er, R., Schindler, M. (2017). Dual role of the chro­matin-bind­ing fac­tor PHF13 in the pre- and post-inte­gra­tion phas­es of HIV‑1 repli­ca­tion. Open Biol­o­gy, 7: pii: rsob.170115.

Hot­ter, D., Sauter, D., Kirch­hoff, F. (2017). Guany­late bind­ing pro­tein 5: impair­ing viri­on infec­tiv­i­ty by tar­get­ing retro­vi­ral enve­lope gly­co­pro­teins. Small GTPas­es, 8: 31 – 37.

Hot­ter, D., Krabbe, T., Rei­th, E., Gawan­bacht, A., Rahm, N., Ayou­ba, A., Van Driess­che, B., Van Lint, C., Peeters, M., Kirch­hoff, F., Sauter, D. (2017). Pri­mate lentivirus­es use at least three alter­na­tive strate­gies to sup­press NF-κB-medi­at­ed immune acti­va­tion. PLoS Pathog, 13: e1006598.

Jøns­son, K.L., Laust­sen, A., Krapp, C., Skip­per, K.A., Thavachel­vam, K., Hot­ter, D., Egedal, J.H., Kjol­by, M., Moham­ma­di, P., Prabakaran, T., Sørensen, L.K., Sun, C., Jensen, S.B., Holm, C.K., Leb­bink, R.J., Johannsen, M., Nye­gaard, M., Mikkelsen, J.G., Kirch­hoff, F., Palu­dan, S.R., Jakob­sen, M.R. (2017). IFI16 is required for DNA sens­ing in human macrophages by pro­mot­ing pro­duc­tion and func­tion of cGAMP. Nat Com­mun, 8:14391.

Man­rique, S., Sauter, D., Horenkamp, F.A., Lülf, S., Yu, H., Hot­ter, D., Anand, K., Kirch­hoff, F., Gey­er, M. (2017). Endo­cyt­ic sort­ing motif inter­ac­tions involved in Nef-medi­at­ed down­mod­u­la­tion of CD4 and CD3. Nat Com­mun, 8:442.

Langer, S., Sauter, D. (2017). Unusu­al Fusion Pro­teins of HIV‑1. Front Micro­bi­ol, 7:2152.

Li, Y., Sun, B., Ess­er, S., Jessen, H., Streeck, H., Widera M., Yang, R., Dittmer, U., Sut­ter, K. (2017). Expres­sion Pat­tern of Indi­vid­ual IFNA Sub­types in Chron­ic HIV Infec­tion. J Inter­fer­on Cytokine Res, 37:541 – 549.

Trautz, B., Wiede­mann, H., Lücht­en­borg, C., Pieri­ni, V., Kranich, J., Glass, B., Kräus­slich, H.G., Brock­er, T., Piz­za­to, M., Rug­gieri, A., Brüg­ger, B., Fack­ler, O.T. (2017). The host-cell restric­tion fac­tor SERINC5 restricts HIV‑1 infec­tiv­i­ty with­out alter­ing the lipid com­po­si­tion and orga­ni­za­tion of viral par­ti­cles. J Biol Chem, 292:13702 – 13713.

2016

Trautz, B., Pieri­ni, V., Wom­bach­er, R., Stolp, B., Chase, A.J., Piz­za­to, M., Fack­ler, O.T. (2016). The antag­o­nism of HIV Nef to SERINC5 par­ti­cle infec­tiv­i­ty restric­tion involves the coun­ter­ac­tion of viri­on-asso­ci­at­ed pools of the restric­tion fac­tor. J Virol, 90:10915 – 10927.

Xu, S., Ducroux, A., Pon­nu­rangam, A., Franz, S., Vieyres, G., Müsken, M., Zillinger, T., Malas­sa, A., Ewald, E., Hor­nung, V., Bar­chet, W., Häus­sler, S., Pietschmann, T., Goffinet, C. (2016). cGAS-medi­at­ed innate immu­ni­ty spreads inter­cel­lu­lar­ly through HIV‑1 Env-induced mem­brane fusion sites Cell Host Microbe, 20:443 – 457.