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ProjectsAndreaSaidi2021-10-05T10:11:23+02:00

Norbert Bannert /​ Oya Cingöz

Innate sens­ing and cel­lu­lar restric­tion fac­tors tar­get­ing endoge­nous retro­virus­es and HIV‑1

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Ulf Dittmer /​ Kathrin Sutter /​ Barbara Sitek

Reg­u­la­tion of the induc­tion of IFNα sub­types dur­ing HIV infection

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Oliver Fackler

Antag­o­nism of host cell restric­tion and sens­ing by HIV‑1 Nef

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Christine Goffinet

Mod­u­la­tion of cell-intrin­sic innate immu­ni­ty to improve “shock-and-kill” strate­gies of HIV‑1 cure

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Oliver Keppler /​ Veit Hornung

Cel­lu­lar and Viral Deter­mi­nants of Innate HIV Recog­ni­tion in Macrophages

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Frank Kirchhoff

Role of IFI16 in retro­vi­ral restric­tion and immune sensing

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Renate König

Inves­ti­ga­tion of cel­lu­lar mech­a­nisms of PQBP1-depen­dant innate sig­nal­ing of HIV‑1

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Hans-Georg Kräusslich

Cap­sid-depen­dent innate sens­ing and restric­tion of retro­vi­ral repli­ca­tion complexes

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Eicke Latz /​ Florian Schmidt

Inves­ti­ga­tion of Innate Immune Respons­es against HIV with Camelid Nanobodies

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Carsten Münk

USP18 mod­u­lates the sens­ing of HIV‑1

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Stefan Pöhlmann /​ Marina Rodnina

Analy­sis of the Role of Shift­less in HIV Infec­tion: Antivi­ral Mech­a­nism and Con­tri­bu­tion to the Innate Immune Response
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Alessia Ruggieri /​ Oliver Fackler

The Role of TREX1 for Innate Sens­ing of Human Endoge­nous Retroviruses

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Daniel Sauter

Tran­scrip­tion­al reg­u­la­tion of innate immu­ni­ty – inter­play of exoge­nous and endoge­nous retroviruses

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Michael Schindler

Coun­ter­ac­tion of innate sens­ing and retro­vi­ral restric­tion by patient-derived HIV‑1 Vpr

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Konstantin Sparrer

The role of bystander cell autophagy in HIV‑1 infection

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Marek Widera

Inter­fer­on-induced alter­ation of cel­lu­lar fac­tors affect­ing HIV alter­na­tive splic­ing, nuclear mRNA export and LTR transcription

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Projects SPP1923

  • Innate sensing and cellular restriction factors targeting endogenous retroviruses and HIV‑1 (Bannert/​Cingöz)
  • Regulation of the induction of IFNα subtypes during HIV infection (Dittmer/​Sutter/​Sitek)
  • Antagonism of host cell restriction and sensing by HIV‑1 Nef (Fackler)
  • Modulation of cell-intrinsic innate immunity to improve “shock-and-kill” strategies of HIV‑1 cure (Goffinet)
  • Cellular and Viral Determinants of Innate HIV Recognition in Macrophages (Keppler/​Hornung)
  • Role of IFI16 in retroviral restriction and immune sensing (Kirchhoff)
  • Investigation of cellular mechanisms of PQBP1-dependant innate signaling of HIV‑1 (König)
  • Capsid-dependent innate sensing and restriction of retroviral replication complexes (Kräusslich)
  • Investigation of Innate Immune Responses against HIV with Camelid Nanobodies (Latz/​Schmidt)
  • USP18 modulates the sensing of HIV‑1 (Münk)
  • Analysis of the Role of Shiftless in HIV Infection: Antiviral Mechanism and Contribution to the Innate Immune Response (Pöhlmann/​Rodnina)
  • The Role of TREX1 for Innate Sensing of Human Endogenous Retroviruses (Ruggieri/​Fackler)
  • Transcriptional regulation of innate immunity – interplay of exogenous and endogenous retroviruses (Sauter)
  • Counteraction of innate sensing and retroviral restriction by patient-derived HIV‑1 Vpr (Schindler)
  • The role of bystander cell autophagy in HIV‑1 infection (Sparrer)
  • Interferon-induced alteration of cellular factors affecting HIV alternative splicing, nuclear mRNA export and LTR transcription (Widera)
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